The 3Dconnexion devices have a plug-in for NX called "3Dconnexion Plug-In for NX" or "3DxNX" for short. However, if the NX version you have is one of the NX Series 1847 it is necessary to make a few changes.

SpaceMouse input in Adobe Reader DC might be blocked by a security feature in Adobe Reader DC.

Open Solid Edge. Go to "Settings-> Add-Ins ...". Verify in the list of available add-ins the entry named "3Dcontrol" is activated.

Check if your application supports 3D Mice. There is a list of such application on the 3Dconnexion site.

3Dconnexion is aware that some early batches of our CadMouse product line show signs of premature aging. This includes defect buttons or wheels and cosmetic problems of the metallic frame.